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Codeine Tablets


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Acetaminophen/codeine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options

Tolerance, dependence, and addiction

  • Risk factors: Taking more than the prescribed dose | Long-term use | History of drug abuse | Younger age

Black Box WarningIf taken regularly for a long time, acetaminophen/codeine can cause physical dependence and tolerance. This means that you may need larger doses to get the same pain relief, and you may experience withdrawal symptoms if the medication is suddenly stopped. Don’t take more than what’s prescribed to you and talk to your healthcare provider about alternatives if this is a concern.

Slowed breathing

  • Risk factors: Age 65 or greater or being frail | High dosages | History of lung problems | Taking other painkillers, benzodiazepines, or sedatives | Certain genetics that ‘activate’ codeine faster

Black Box WarningTaking high doses of acetaminophen/codeine can cause irregular or slow breathing, which can be life-threatening. Use the lowest effective dose for the shortest amount of time. Check with your pharmacist to see if other medications you are taking can make these effects worse. Don’t drink alcohol while taking acetaminophen/codeine. If you are at high risk of breathing problems, your provider may prescribe naloxone, the reversal agent for opioid overdose.

High risk to children

Black Box WarningChildren are more sensitive to codeine and have higher risk of overdose. Even one dose of acetaminophen/codeine can be deadly to children who aren’t used to taking this medication. Some who took codeine for pain after tonsil or adenoid surgery died because of lack of breathing. Due to this high risk, acetaminophen/codeine should not be given to children younger than 12 years of age, or to those younger than 18 years of age if they recently had tonsil or adenoid surgery. Keep this medication out of reach from children. If you suspect your child has taken acetaminophen/codeine, call 911 right away if you notice signs of fatigue, sleepiness, and slowed breathing.

Liver failure

  • Risk factors: Current liver disease | Taking acetaminophen/codeine with alcohol | Taking other medicines containing acetaminophen

Black Box WarningAcetaminophen in acetaminophen/codeine can cause damage to your liver. Taking more than 4,000 mg of acetaminophen daily can cause liver failure or even death. Acetaminophen is also found in many over-the-counter and prescription products. Talk to your local pharmacist to make sure you’re not taking too much.

Death of newborn babies from opioid withdrawal

  • Risk factors: Long-term use during pregnancy

Black Box WarningLet your healthcare provider know if you took acetaminophen/codeine and/or other opioids during pregnancy. Your baby may need special care after birth to prevent potentially fatal withdrawal symptoms.

Drug interactions | Buy Codeine Online No Script

There are many medications that affect the specific liver enzymes responsible for ‘activating’ codeine in the body. Starting or stopping these medications can make acetaminophen/codeine work too strongly (which causes side effects like slowed breathing and drowsiness), or not well enough (which can lead to withdrawal symptoms and poor pain control). It’s best to let your provider and pharmacist know all the medications that you take, including over-the-counter medicines and supplements.

Low blood pressure and low stress hormone levels

  • Risk factors: Existing low blood pressure | Dehydration | Taking other medications that can lower blood pressure | Taking acetaminophen/codeine long-term

Acetaminophen/codeine can cause low blood pressure. If you are already prone to having low blood pressure, let your provider know. Make sure you take the lowest dose necessary, and be extra careful when you stand up or walk around. Rarely, taking acetaminophen/codeine for a long time can also lower stress hormone levels in the body (adrenal insufficiency). Common signs of this condition include nausea, vomiting, poor appetite, fatigue, weakness, dizziness, and low blood pressure. If you notice any of these symptoms, let your provider know immediately.

Severe allergic reactions

Acetaminophen/codeine can cause serious allergic reactions. Signs include swelling of face, mouth, throat, hives, itchiness, and vomiting. If you develop any of these symptoms, stop the medication and get medical help right away. Before starting acetaminophen/codeine, talk to your healthcare provider if you’ve had an allergic reaction to Tylenol, Percocet, codeine, morphine, or sulfites.


  • Risk factors: Seizure conditions

If you have seizure conditions such as epilepsy, the codeine in acetaminophen/codeine can make you more likely to have more seizures. Talk to your provider before starting this medication.


If you have been taking acetaminophen/codeine every day for an extended period of time, do not suddenly stop taking this medication since you can experience opioid withdrawal, which includes symptoms such as anxiety, nausea, diarrhea, and abdominal pain. If you’ve been on acetaminophen/codeine or other opioid medications long-term, it’s best to cut back on your dose gradually.

Interactions between acetaminophen/codeine and other medications

Acetaminophen/codeine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with acetaminophen/codeine. Please note that only the generic name of each medication is listed below.

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